中国中医科学院中药研究所所长——陈士林

陈士林，首席研究员，现任中国中医科学院中药研究所所长，世界卫生组织传统医学合作中心主任，国际欧亚科学院院士，CGCM(中药全球化联盟)副主席。曾任中国医学科学院药用植物研究所所长、香港理工大学客座教授，并在英国皇家植物园丘园接受专业培训、哈佛医学院Mclean医院做访问学者等。现兼任日本东京药科大学客座教授、美国药典传统中药咨询组委员等。为教育部长江学者和创新团队计划负责人，担任APSB，Chinese Medicine，CHM，《药学学报》等刊副主编。

陈士林在国际上创建了基于ITS2的中草药DNA条形码鉴定方法体系，完成专著《中国药典中药材DNA条形码标准序列》，从基因层面解决中草药物种真伪鉴定的难题，被评为2016中国十大医学进展;通过全基因组解析提出灵芝为首个中药基原药用模式真菌，被Nature China 选为中国最佳研究亮点推];完成并发表人参、丹参、赤芝、菊花、卷柏、穿心莲、紫芝等全基因组图谱和相关组学研究，成功培育并获批6个中药材新品种证书或良种证书，主编并开拓奠定《本草基因组学》学科基础并由科学出版社出版，列为全国高等医药院校规划教材;完成并编著《中国药材产地生态适宜性区划》，主持无公害种植项目成功推广应用;

获吴阶平医药创新奖 、Agilent Thought Leadership Award、岐黄学者等荣誉，获教育部高校成果科技进步一等奖1项，国家科技进步二等奖3项。获国家发明专利和美国专利授权38项，发表论文400余篇，其中SCI 论文200余篇，包括国际著名期刊Nature Communications, Mol Plant、PNAS等，论文被他引1.6万余次，H指数61(Google Scholar),连续五年入选Elsevier高被引中国学者榜单。

主要论文：

1.Shilin Chen*.; Xu, J.; Liu, C.; Zhu, Y.; Nelson, D. R.; Zhou, S.; Li, C.; Wang, L.; Guo, X.; Sun, Y.; H Luo, Y Li, J Song, B Henrissat, A Levasseur, J Qian, J Li, X Luo, L Shi, LHe, L Xiang, X Xu, Y Niu, Q Li, Mira V. Han, H Yan, J Zhang, H Chen, A Lv, ZWang, M Liu, David C. Schwartz & C Sun*. Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nature communications 2012, 3, 913. [6]

2. Song, C; Liu, Y; Song, A; Dong, G; Zhao, H; Sun, W; Ramakrishnan, Shyam; Wang, Y; Wang, S; Li, T; Niu, Y; Jiang, J; Dong, B; Xia, Y; Chen, S; Hu, Z; Chen, F; Chen, Shilin The Chrysanthemum nankingense genome provides insights into the evolution and diversification of chrysanthemum flowers and medicinal traits. Molecular plant, 2018 Vol: 11(12): 1482-1491

3. Shilin Chen*.; Song, J.; Sun, C.; Xu, J.; Zhu, Y.; Verpoorte, R.; Fan, T.-P.*, Herbal genomics: Examining the biology of traditional medicines. Science 2015,347(6219), S27-S29.

4. Xu J , Chu Y, Liao B, Xiao S, Yin Q, Bai R, Su H, Dong L, Li X, Qian J, Zhang J, Zhang Y, Zhang X, Wu M, Zhang J, Li G, Zhang L, Chang Z, Zhang Y, Jia Z, Liu Z, Daniel Afreh, Ruth Nahurira8, Zhang L, Cheng R, Zhu Y, Zhu G, Rao W, Zhou C, Qiao L, Huang Z, Cheng Yung-Chi, Chen Shilin, Panax ginseng genome examination for ginsenoside biosynthesis GigaScience doi: 10.1093 gix093, 2017

5. Sun W; Leng L; Yin Q; Xu M; Huang M; Xu Z; Zhang Y; Yao H; Wang C; Xiong C; Chen S; Jiang C; Xie N; Zheng X; Wang Y; Song C; Reuben J. Peters， The medicinal plant Andrographis paniculate genome provides insight into biosynthesis of the bioactive diterpenoid neoandrographolide,Plant J 2018

6. China Plant BOL Group, DZ LI et al., Comparative ysis of a large dataset indicates that internal transcribed spacer (ITS) should be incorporated into the core barcode for seed plants. Proceedings of the National Academy of Sciences of the USA 2011, 108, 19641-19646.

7. Z Xu, T Xin, Dorothea Bartels,Y Li, W Gu,H Yao,S Liu,H Yu,X Pu, J Zhou, J Xu, C Xi ,H Lei Jingyuan Song,Shilin Chen.Genome ysis of the ancient tracheophyte Selaginella tamariscinareveals evolutionary features relevant to the acquisition of desiccation tolerance. Mol Plant 2018 [37].

8. Xu, Z.; Peters, R. J.; Weirather, J.; Luo, H.; Liao, B.; Zhang, X.; Zhu, Y.; Ji, A.; Zhang, B.; Hu, S.; Au, K. F.; Song, J*.; Shilin Chen*, Full-length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues of Salvia miltiorrhiza and tanshinone biosynthesis. The Plant Journal 2015.

9. ShiLin Chen*.; Pang, X.; Song, J.; Shi, L.; Yao, H.; Han, J.; Leon, C., A renaissance in herbal medicine identification: from morphology to DNA. Biotechnology Advances 2014, 32 (7), 1237-1244.

10. H Xu, J Song, H Luo, Y Zhang, Q Li, Y Zhu, J Xu, Y Li, C Song, B Wang, W Sun, G Shen, X Zhang, J Qian, A Ji, Z Xu, X Luo, L He, C Li, C Sun, H Yan, G Cui, X Li, Xi Li, J Wei, J Liu,Y Wang, A Hayward, D Nelson, Z Ning, RJ. Peters, X Qi, S Chen. Analysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza Mol Plant 2016, Volume 9, Issue 6, p949–952 [7].

11. Pang, X.; Song, J.; Zhu, Y.; Xu, H.; Huang, L.; ShiLin Chen*. Applying plant DNA barcodes for Rosaceae species identification. Cladistics 2011, 27 (2), 165-170.

12. Zhu, Y.; Luo, H.; Zhang, X.; Song, J.; Sun, C.; Ji, A.; Xu, J.; ShiLin Chen*., Abundant and selective RNA-editing events in the medicinal mushroom Ganoderma lucidum. Genetics 2014, 196 (4), 1047-1057.

13. Li, X.; Yang, Y.; Henry, R. J.; Rossetto, M.; Wang, Y.; ShiLin Chen*, Plant DNA barcoding: from gene to genome. Biological Reviews 2015, 90 (1), 157-166.

14. D Zhang; C Jiang; C Huang; D Wen; J Lu; S Chen; T Zhang; Y Shi; J Xue; W Ma; L Xiang; W Sun; Shilin Chen, The light-induced transcription factor FtMYB116 promotes accumulation of rutin in Fagopyrum tataricum. Plant Cell & Environment 2018

15. Jung Chao Yuntao Dai Robert Verpoorted Wing Lame Yung-Chi Chenge Li-Heng Pao Wei Zhang Shilin Chen Major achievements of evidence-based traditional Chinese medicine in treating major diseases Biochemical Pharmacology Volume139, 1 September 2017, Pages 94-10

16. Huang Z,, Xu J,, Xiao S, Liao B, Gao Y, Zhai C, Qiu X, Xu W and Chen Shilin. Comparative optical genome ysis of two pangolin species: Manis pentadactyla and Manis javanica. Giga Science 2016,5, 1-5

17. Li, Q.; Li, Y.; Song, J.*; Xu, H.; Xu, J.; Zhu, Y.; Li, X.; Gao, H.; Dong, L.; Qian, J.; Sun, C, Shilin Chen*., High-accuracy de novo assembly and SNP detection of chloroplast genomes using a SMRT circular consensus sequencing strategy. New Phytologist 2014, 204 (4), 1041-1049.

18. C Wang, X Su, W Sun, S Zhou, J Zheng, M Zhang, M Sun, J Xue, X Liu, J Xing, Shilin Chen., Efficient production of succinic acid from herbal extraction residue hydrolysate, Bioresource Technology 2018

19. LL Dong, J Xu ,Y Li,H Fang,W Niu,X Li,Y Zhang,W Ding,SL Chen, Manipulation of microbial community in the rhizosphere alleviates the replanting issues in Panax ginseng。Soil Biology and Biochemistry Volume 125, October 2018, Pages 64-74

20. R Shi, Z Hu, H Lu, L Liu, L Xu, Y Liu, H Wu, B Huang, G Zhang,* S Chen,* F Yang*, Hierarchical Nanostructuring Array Enhances Mid-Hybridization for Accurate Herbal Identification via ITS2 DNA Barcode. Analytical Chemistry, 2019, doi: 10.1021.

来源：中国中医科学院中药研究所